Biological Activity
Endogenous antiopioid peptide and agonist at NPFF1 and NPFF2 receptors (Ki values are 2.82 and 0.21 nM respectively). Exhibits anorexigenic effects following i.c.v. administration.
Technical Data
| M. Wt | 1081.28 |
| Formula | C54H76N14O10 |
| Sequence |
FLFQPQRF (Modifications: Phe-8 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 99566-27-5 |
| PubChem ID | 9854861 |
| InChI Key | HWYCFZUSOBOBIN-AQJXLSMYSA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 0.50 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1081.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.92 mL | 4.62 mL | 9.25 mL |
| 5 mM | 0.18 mL | 0.92 mL | 1.85 mL |
| 10 mM | 0.09 mL | 0.46 mL | 0.92 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.18 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Cline et al (2007) Central neuropeptide FF reduces feed consumption and affects hypothalamic chemistry in chicks. Neuropeptides 41 433 PMID: 17936900
Gouarderes et al (2007) Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of[35S]GTPγS binding. Neuropharmacology 52 376 PMID: 17011599
Keywords: Neuropeptide FF, supplier, Endogenous, NPFF1, NPFF2, agonists, Anti-opioids, NPFFR1, NPFFR2, Receptors, Neuropeptides, FF/AF, NeuropeptideFF, Miscellaneous/Non-selective, Opioids, Neuropeptide, FF/AF, Receptors, Neuropeptide, FF/AF, Receptors, Tocris Bioscience
