![Tocris/[D-Trp34]-Neuropeptide Y/3436/200U/200 ug](https://www.ebiomall.cn/images/201712/1512521756115821138.jpg)
Biological Activity
Potent neuropeptide Y (NPY) Y5 receptor agonist (pEC50 values are 7.82, 6.28, 6.44 and > 6 at rat Y5, Y4, Y1 and Y2 receptors respectively) that displays > 26-fold, > 1000-fold and > 1000-fold selectivity over Y1, Y2 and Y4 receptors respectively. Induces hyperphagia, body weight gain, adiposity, hypercholesterolemia, hyperinsulinemia and hyperleptinemia in vivo. Orally active.
Technical Data
| M. Wt | 4311.77 |
| Formula | C196H289N55O56 |
| Sequence |
YPSKPDNPGEDAPAEDLARYYSALRHYINLITRWRY (Modifications: Trp-34 = D-Trp, Tyr-36 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 153549-84-9 |
| PubChem ID | 16132265 |
| InChI Key | IDLFZVILOHSSID-OVLDLUHVSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 0.20 mg/ml in 20% acetonitrile |
Preparing Stock Solutions
The following data is based on the product molecular weight 4311.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 5 mM | 0.05 mL | 0.23 mL | 0.46 mL |
| 10 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| 50 mM | 0 mL | 0.02 mL | 0.05 mL |
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References
References are publications that support the products' biological activity.
Parker et al (2000) [D-Trp34] neuropeptide Y is a potent and selective neuropeptide Y Y5 receptor agonist with dramatic effects on food intake. Peptides 21 393 PMID: 10793222
Mashiko et al (2003) Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: chronic intracerebroventricular infusion of D-Trp34NPY. Endocrinology 144 1793 PMID: 12697685
Beck et al (2007) Responsiveness of obese Zucker rats to [D-Trp34]-NPY supports the targeting of Y5 receptor for obesity treatment. Nutr.Neurosci. 10 211 PMID: 18284029
Keywords: [D-Trp34]-Neuropeptide Y, supplier, Potent, NPY, Y5, agonists, orexigenic, Neuropeptide, Y, Receptors, [D-Trp34]-NeuropeptideY, neuropeptides, NPY, Receptors, NPY, Receptors, Tocris Bioscience
