Biological Activity
α-adrenergic, vasodilator. Cognitive enhancer.
Technical Data
| M. Wt | 484.39 |
| Formula | C24H26BrN3O3 |
| Storage | Store at RT |
| CAS Number | 27848-84-6 |
| PubChem ID | 90479736 |
| InChI Key | GCNGMFQQSBSPIJ-XPXYHQFPSA-N |
| Smiles | [H][C@](COC(C5=CN=CC(Br)=C5)=O)1C[C@@](C2=CC=CC3C2C(C4)=CN3C)(OC)[C@]4([H])N(C1)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.43 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 484.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.06 mL | 10.32 mL | 20.64 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.13 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.06 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Carfagna et al (1995) Modulation of hippocampal ACh release by chronic nicergoline treatment in freely moving young and aged rats. Neurosci.Lett. 197 195 PMID: 8552297
Carfagna et al (1996) Modulation of phosphoinositide turnover by chronic nicergoline in rat brain. Neurosci.Lett. 209 189 PMID: 8736642
Chopin and Briley (1992) Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats. Psychopharmacology 106 26 PMID: 1738791
Merck Index 12 6580 PMID:
Keywords: Nicergoline, supplier, α-adrenoceptor, alpha-adrenoceptor, a-adrenoceptor, antagonists, α-adrenergic, alpha-adrenergic, a-adrenergic, Receptors, Non-Selective, vasodilator, Non-selective, Adrenergic, Alpha, Receptors, Non-selective, Adrenergic, Alpha, Receptors, Tocris Bioscience
