Biological Activity
L-type Ca2+ channel blocker.
Technical Data
| M. Wt | 418.45 |
| Formula | C21H26N2O7 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 66085-59-4 |
| PubChem ID | 4497 |
| InChI Key | UIAGMCDKSXEBJQ-UHFFFAOYSA-N |
| Smiles | COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(=C1)[N+]([O-])=O)C(=O)OC(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.84 | 100 | |
| ethanol | 4.18 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 418.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.39 mL | 11.95 mL | 23.9 mL |
| 5 mM | 0.48 mL | 2.39 mL | 4.78 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.39 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Batuecas et al (1998) Effects of chronic nimodipine on working memory of old rats in relation to defects in synaptosomal calcium homeostasis. Eur.J.Pharmacol. 350 141 PMID: 9696401
Izquierdo (1990) Nimodipine and the recovery of memory. TiPS 11 309 PMID: 2203191
Kappelle et al (1994) Beneficial effect of the Ca2+ antagonist, nimodipine, on existing diabetic neuropathy in the BB/Wor rat. Br.J.Pharmacol. 111 887 PMID: 8019766
Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9 PMID: 21164513
Keywords: Nimodipine, supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, Voltage-gated, Calcium, Channels, Autophagy, Voltage-gated, Calcium, Channels, Tocris Bioscience
