Biological Activity
Reversible, competitive and non-selective NOS inhibitor. Monosodium salt 7-NINA (Cat. No. 0800) also available.
Compound Libraries
7-Nitroindazole is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 163.14 |
| Formula | C7H5N3O2 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2942-42-9 |
| PubChem ID | 1893 |
| InChI Key | PQCAUHUKTBHUSA-UHFFFAOYSA-N |
| Smiles | [O-][N+](=O)C1=C2NN=CC2=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
Preparing Stock Solutions
The following data is based on the product molecular weight 163.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.13 mL | 30.65 mL | 61.3 mL |
| 5 mM | 1.23 mL | 6.13 mL | 12.26 mL |
| 10 mM | 0.61 mL | 3.06 mL | 6.13 mL |
| 50 mM | 0.12 mL | 0.61 mL | 1.23 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Babbedge et al (1993) Inhibition of rat cerebellar nitric oxide synthase by 7-nitroindazole and related substituted indazoles. Br.J.Pharmacol. 110 225 PMID: 7693279
Moore et al (1993) 7-nitroindazole, an inhibitor of nitric oxide synthase, exhibits antinociceptive activity in the mouse without increasing blood pressure. Br.J.Pharmacol. 108 296 PMID: 7680591
Moore et al (1993) Characterisation of the novel nitric oxide synthase inhibitor 7-nitroindazole and related indazoles: antinociceptive and cardiovascular effects. Br.J.Pharmacol. 110 219 PMID: 7693278
Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPS 18 204 PMID: 9226999
Keywords: 7-Nitroindazole, supplier, Non-Selective, NOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Synthases, Non-selective, NOS, Non-selective, NOS, Tocris Bioscience
