Biological Activity
Orphan neuropeptide, flanking nociceptin in the precursor pronociceptin. Stimulates locomotion in mice, possibly through a novel specific receptor.
Technical Data
| M. Wt | 2081.4 |
| Formula | C92H141N23O28S2 |
| Sequence | FSEFMRQYLVLSMQSSQ |
| Storage | Desiccate at -20°C |
| CAS Number | 188119-47-3 |
| PubChem ID | 90479756 |
| InChI Key | PPKKOTLGXBHLAB-XVHSACDVSA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 2081.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.48 mL | 2.4 mL | 4.8 mL |
| 5 mM | 0.1 mL | 0.48 mL | 0.96 mL |
| 10 mM | 0.05 mL | 0.24 mL | 0.48 mL |
| 50 mM | 0.01 mL | 0.05 mL | 0.1 mL |
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Product Datasheets
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References
References are publications that support the products' biological activity.
Florin et al (1997) Orphan neuropeptide NocII, a putative pronociceptin maturation product, stimulates locomotion in mice. NeuroReport 8 705 PMID: 9106751
Florin et al (1999) Comparison of behavioural effects of NocII or NocIII, two related pronociceptin-derived peptides. Life Sci. 65 2727 PMID: 10622282
Keywords: NocII, supplier, Orphan, neuropeptide, Nociceptin, Receptors, ORL1, OP4, NOP, Opioid, neuropeptides, NOP, Receptors, NOP, Receptors, Tocris Bioscience
