Biological Activity
Bioactive metabolite of nociceptin. Antagonizes nociceptin-induced hyperalgesia, with no effect on nociceptin-induced analgesia.
Technical Data
| M. Wt | 655.7 |
| Formula | C31H41N7O9 |
| Sequence | FGGFTGA |
| Storage | Desiccate at -20°C |
| CAS Number | 178249-42-8 |
| PubChem ID | 71353398 |
| InChI Key | KVTLKXLQUDUFSD-FLSSTNBBSA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 2 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 655.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.53 mL | 7.63 mL | 15.25 mL |
| 5 mM | 0.31 mL | 1.53 mL | 3.05 mL |
| 10 mM | 0.15 mL | 0.76 mL | 1.53 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.31 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Montiel et al (1997) Nociceptin/orphanin FQ metabolism: role of aminopeptidase and endopeptidase 24.15. J.Neurochem. 68 354 PMID: 8978746
Sakurada et al (1999) Nociceptin (1-7) antagonizes nociceptin-induced hyperalgesia in mice. Br.J.Pharmacol. 128 941 PMID: 10556929
Keywords: Nociceptin (1-7), supplier, Bioactive, metabolite, nociceptin, Receptors, ORL1, OP4, NOP, Opioid, NOP, Receptors, NOP, Receptors, Tocris Bioscience
