Tocris/Nutlin-3/3984/50/50毫克-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/Nutlin-3/3984/50/50毫克

Tocris/Nutlin-3/3984/50/50毫克

商品编号： 3984/50

品牌： Tocris Bioscience

市场价： ¥20500.00

美元价： 12300.00

产地：美国(厂家直采)

公司：

产品分类：连接酶

公司分类： ligase

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

Description:MDM2antagoNIST;inhibitsMDM2-p53interaction

ChemicalName:(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

MDM2antagonist;inhibitstheMDM2-p53interaction(IC₅₀=0.09μM)andactivatesp53.Antiproliferativeagent;inducesapoptosisincancercells.

LicensingInformation

SoldunderlicensefromF.Hoffmann-LaRocheLtd.

CompoundLibraries

Nutlin-3isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	581.49
Formula	C₃₀H₃₀Cl₂N₄O₄
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	548472-68-0
PubChemID	16755649
InChIKey	BDUHCSBCVGXTJM-IZLXSDGUSA-N
Smiles	ClC1=CC=[C@@]([C@@H]3[C@@H](N(C(N5CC(NCC5)=O)=O)C(C4=CC=C(OC)C=C4OC(C)C)=N3)[C@]2=CC=C(Cl)C=C2)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	58.15	100
	ethanol	58.15	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight581.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.72mL	8.6mL	17.2mL
5mM	0.34mL	1.72mL	3.44mL
10mM	0.17mL	0.86mL	1.72mL
50mM	0.03mL	0.17mL	0.34mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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