Biological Activity
Originally defined as a high affinity cannabinoid CB1 receptor silent antagonist. Acts as a partial agonist in inhibiting forksolin-induced cyclic AMP stimulation (EC50 = 40.4 nM). Decreases food intake and stimulates locomotor activity in rodents. Antagonizes effects of CP55,940 (Cat. No. 0949) in vitro.
Licensing Information
Sold under license from VCU-IPF
Technical Data
| M. Wt | 417.56 |
| Formula | C23H31NO4S |
| Storage | Store at -80°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 851320-29-1 |
| PubChem ID | 16102146 |
| InChI Key | DJTGGIYZQHHLGJ-RTBURBONSA-N |
| Smiles | OC1=CC(CC#CCCCNS(=O)(C)=O)=CC3=[C@@]1[C@@H]2CC(C)=CC[C@H]2[C@@](C)(C)O3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.76 | 100 | |
| ethanol | 41.76 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 417.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.39 mL | 11.97 mL | 23.95 mL |
| 5 mM | 0.48 mL | 2.39 mL | 4.79 mL |
| 10 mM | 0.24 mL | 1.2 mL | 2.39 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Gardner and Mallet (2006) Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist.' Eur.J.Pharmacol. 530 103 PMID: 16380113
Martin et al (2002) Agonists and silent antagonists in a series of cannabinoid sulfonamides. Symposium on the Cannabinoids, International Canna PMID:
Wiley et al (2011) Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB1 receptor antagonist. Eur.J.Pharmacol. 651 96 PMID: 21114999
Keywords: O-2050, supplier, CB1, silent, antagonists, cannabinoids, receptors, cb1r, receptor, CB1, Receptors, CB1, Receptors, Tocris Bioscience
