Biological Activity
Potent endogenous vanilloid TRPV1 (VR1) receptor agonist (EC50 = 36 nM at hVR1) with low affinity for rCB1 receptors (Ki = 1.6 μM). Potently induces VR1-mediated thermal hyperalgesia in rats in vivo.
Technical Data
| M. Wt | 417.63 |
| Formula | C26H43NO3 |
| Storage | Desiccate at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 105955-11-1 |
| PubChem ID | 5282106 |
| InChI Key | QQBPLXNESPTPNU-KTKRTIGZSA-N |
| Smiles | CCCCCCCCC=C/CCCCCCCC(=O)NCCC1=CC=C(O)C(O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.88 | 50 | |
| ethanol | 20.88 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 417.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.39 mL | 11.97 mL | 23.94 mL |
| 5 mM | 0.48 mL | 2.39 mL | 4.79 mL |
| 10 mM | 0.24 mL | 1.2 mL | 2.39 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Butelman et al (2004) Anitallodynic effects of loperamide and fentanyl against topical capsaicin-induced allodynia in unanesthetized primates. J.Pharmacol.Exp.Ther. 311 155 PMID: 15152028
Chu et al (2003) N-Oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 278 13633 PMID: 12569099
Keywords: OLDA, supplier, Potent, selective, endogenous, TRPV1, agonists, Vanillioid, Receptors, VR1, TRPV, Channels, Transient, Receptor, Potential, N-Oleoyldopamine, TRPV, TRPV, Tocris Bioscience
