Biological Activity
EP1 receptor antagonist. Exhibits analgesic effect in a mouse mode of cystitis. Orally bioavailable.
Compound Libraries
ONO 8130 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 500.63 |
| Formula | C25H28N2O5S2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 459841-96-4 |
| PubChem ID | 9827317 |
| InChI Key | IOXMDBQCUCDLAF-UHFFFAOYSA-N |
| Smiles | CC(C)CN(S(C3=NC(C)=CS3)(=O)=O)C1=C(OCC4=CC=C(C(O)=O)C=C4)C=C(CCC2)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.06 | 100 | |
| ethanol | 10.01 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 500.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2 mL | 9.99 mL | 19.97 mL |
| 5 mM | 0.4 mL | 2 mL | 3.99 mL |
| 10 mM | 0.2 mL | 1 mL | 2 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Miki et al (2011) ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. Pain 152 1373 PMID: 21396778
Lipina et al (2005) Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia. Psychopharmacology 179 54 PMID: 15759151
Keywords: ONO 8130, supplier, ONO8130, EP1, receptor, antagonists, antagonism, analgesics, cystitis, Prostanoid, Receptors, Prostanoid, Receptors, Tocris Bioscience
