Biological Activity
Potent and selective inhibitor of catechol-O-methyl-transferase.
Technical Data
| M. Wt | 200.11 |
| Formula | C6H4N2O6 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 7659-29-2 |
| PubChem ID | 3870203 |
| InChI Key | VDCDWNDTNSWDFJ-UHFFFAOYSA-N |
| Smiles | OC1=CC(=CC(=C1O)[N+]([O-])=O)[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.01 | 100 | |
| ethanol | 20.01 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 200.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5 mL | 24.99 mL | 49.97 mL |
| 5 mM | 1 mL | 5 mL | 9.99 mL |
| 10 mM | 0.5 mL | 2.5 mL | 5 mL |
| 50 mM | 0.1 mL | 0.5 mL | 1 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Mannisto and Kaakola (1990) Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease. Pharmacol.Toxicol. 66 317 PMID: 2196554
Borgulya et al (1989) Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives: synthesis and structure-activity studies. Helv.Chim.Acta 72 952 PMID:
Keywords: OR-486, supplier, Catechol, O-methyl, transferase, COMT, inhibitors, inhibits, Adrenergic, Related, Compounds, Dopaminergic-Related, Catechol, O-Methyltransferase, Catechol, O-Methyltransferase, Tocris Bioscience
