BiologicalActivity
PDPK1(PDK1)inhibitor;inhibitsAktsignaling.InducesapoptosisofPC-3andmedulloblastomacells,andinhibitsgrowthofanumberoftumorcelllines.SensitizesrADIotherapy-inducedcelldeathandenhancescytotoxiceffectsofchemotherapeuticagentsinvitro.Attenuatestumorgrowthofmedulloblastomaxenograftsinmice.
CompoundLibraries
OSU03012isalsoofferedaspartoftheTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 460.45 |
| Formula | C26H19F3N4O |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 742112-33-0 |
| PubChemID | 10027278 |
| InChIKey | YULUCECVQOCQFQ-UHFFFAOYSA-N |
| Smiles | O=C(CN)NC(C=C1)=CC=C1N2C(C(C=C3)=CC4=C3C5=CC=CC=C5C=C4)=CC(C(F)(F)F)=N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.05 | 100 | |
| ethanol | 9.21 | 20mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight460.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.17mL | 10.86mL | 21.72mL |
| 5mM | 0.43mL | 2.17mL | 4.34mL |
| 10mM | 0.22mL | 1.09mL | 2.17mL |
| 50mM | 0.04mL | 0.22mL | 0.43mL |
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ProductDatasheets
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