Biological Activity
Dopamine stabilizer; lacks high affinity for various neuroreceptors in vitro (Ki values are 447 and 1305 nM for D2 and D3 receptors respectively and > 1 μM for other targets). Exhibits high D2 receptor occupancy in vivo; highly active on dopamine synthesis and turnover. Induces stabilizing effects on psychomotor function in behavioral tests without inducing hypolocomotion or catalepsy.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data
| M. Wt | 317.87 |
| Formula | C15H23NO2S.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 156907-84-5 |
| PubChem ID | 9836644 |
| InChI Key | LEMGVHZVBREXAD-PFEQFJNWSA-N |
| Smiles | CCCN(C2)CCC[C@@]2([H])C1=CC=CC(S(=O)(C)=O)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.79 | 100 | |
| water | 31.79 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 317.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.15 mL | 15.73 mL | 31.46 mL |
| 5 mM | 0.63 mL | 3.15 mL | 6.29 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.15 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Nichols et al (2002) PNU-96391A (OSU6162) antagonizes the development of behavioural sensitization induced by dopamine agonists in a rat model for Parkinson's disease. Neuropharmacology 43 817 PMID: 12384167
Natesan et al (2006) The dopamine stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low po J.Pharmacol.Exp.Ther. 318 810 PMID: 16648369
Rung et al (2005) The dopaminergic stabilizers (-)-OSU6162 and ACR16 reverse (+)-MK-801-induced social withdrawal in rats. Prog.Neuro-Psychopharm.Biol.Psychiat. 29 833 PMID:
Keywords: OSU 6162 hydrochloride, supplier, Dopamine, stabilizer, Dopaminergic, Receptors, OSU6162, hydrochloride, PNU96391, D2, receptor, PNU, 96391, Dopaminergic-Related, Dopaminergic-Related, Tocris Bioscience
