Biological Activity
Potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A (Cat. No. 1455).
Technical Data
| M. Wt | 1749 |
| Formula | C79H125N23O22 |
| Sequence |
YELLHGAGNHAAGILTL (Modifications: Leu-33 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 343268-91-7 |
| PubChem ID | 44376806 |
| InChI Key | JPRBZUXULYLVPJ-HYNYKCRDSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1749. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.57 mL | 2.86 mL | 5.72 mL |
| 5 mM | 0.11 mL | 0.57 mL | 1.14 mL |
| 10 mM | 0.06 mL | 0.29 mL | 0.57 mL |
| 50 mM | 0.01 mL | 0.06 mL | 0.11 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Darker et al (2001) Structure-activity analysis of truncated orexin-A analogues at the orexin-1 receptor. Bioorg.Med.Chem.Lett. 11 737 PMID: 11266181
German et al (2013) Truncated orexin peptides: structure-activity relationship studies. Med.Chem.Lett. 4 1224 PMID: 24707347
Keywords: OXA (17-33), supplier, Potent, selective, orexin, OX1, receptors, agonists, OX1, Receptor, OX1, Receptor, Tocris Bioscience
