Biological Activity
Modulator of GABAA receptors. Displays modest selectivity for GABAA α1 receptors; displays partial agonist activity at α2-, α3- and α5-containing receptors. Exhibits anxiolytic activity.
Technical Data
| M. Wt | 301.3 |
| Formula | C17H11N5O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 96604-21-6 |
| PubChem ID | 216456 |
| InChI Key | OQJFBUOFGHPMSR-UHFFFAOYSA-N |
| Smiles | O=C(C4=CC=CC=N4)C2=C1N=CC=C(C3=CC=NC=C3)N1N=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 2eq.HCl | 30.13 | 100 | |
| DMSO | 3.01 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 301.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.32 mL | 16.59 mL | 33.19 mL |
| 5 mM | 0.66 mL | 3.32 mL | 6.64 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.32 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Mirza et al (2006) Comparative cue generalization profiles of L-838,417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone, and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination. J.Pharmacol.Exp.Ther. 316 1291 PMID: 16339395
Lippa et al (2005) Selective anxiolysis produced by ocinaplon, a GABAA receptor modulator. Proc.Natl.Acad.Sci.USA 102 7380 PMID: 15870187
Rupprecht et al (2006) GABAA receptors as targets for novel anxiolytic drugs. World J.Biol.Psychiatry 7 231 PMID: 17071543
Keywords: Ocinaplon, supplier, gabaa, α1, alpha1, a1, positive, modulators, anxiolytics, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
