Biological Activity
Dynamin inhibitor (IC50 = 1.9 μM for dynamin I). Inhibits receptor-mediated endocytosis (IC50 = 16 μM). Displays similar activity to MitMAB (Cat. No. 4224).
Technical Data
| M. Wt | 392.5 |
| Formula | C21H46BrN |
| Storage | Desiccate at RT |
| CAS Number | 1120-02-1 |
| PubChem ID | 70708 |
| InChI Key | SZEMGTQCPRNXEG-UHFFFAOYSA-M |
| Smiles | CCCCCCCCCCCCCCCCCC[N+](C)(C)C.[Br-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.92 | 10 | |
| ethanol | 39.25 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 392.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.74 mL | 25.48 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.1 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Quan et al (2007) Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II. Mol.Pharmacol. 72 1425 PMID: 17702890
Joshi et al (2010) The dynamin inhibitors MitMAB and OctMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells. Mol.Cancer Ther. 9 1995 PMID: 20571068
Keywords: OctMAB, supplier, dynamin, I, II, inhibitors, inhibits, gtpase, endocytosis, OctMAB, GTPase, Mitosis, GTPase, Tocris Bioscience
