Biological Activity
Endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. Inhibits differentiation of neural stem cells (NSCs) into neurons.
Technical Data
| M. Wt | 458.5 |
| Formula | C21H40NaO7P |
| Storage | Store at -20°C |
| CAS Number | 325465-93-8 |
| PubChem ID | 44159357 |
| InChI Key | XGRLSUFHELJJAB-JGSYTFBMSA-M |
| Smiles | [Na+].CCCCCCCCC=C/CCCCCCCC(=O)OC[C@@H](O)COP(O)([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 4.58 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 458.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.18 mL | 10.91 mL | 21.81 mL |
| 5 mM | 0.44 mL | 2.18 mL | 4.36 mL |
| 10 mM | 0.22 mL | 1.09 mL | 2.18 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
van Corven et al (1992) Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Biochem.J. 281 163 PMID: 1731751
Dottori et al (2008) Lysophosphatidic acid inhibits neuronal differentiation of neural stem/progenitor cells derived from human embryonic stem cells. Stem Cells 26 1146 PMID: 18308941
Lapierre et al (2010) Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival. J.Biol.Chem. 285 25792 PMID: 20551326
Keywords: 1-Oleoyl lysophosphatidic acid sodium salt, supplier, lysophosphatidic, acid, LPA, lysophospholipid, receptors, LPL-R, agonists, Lysophosphatidic, Acid, Receptors, Neural, Stem, Cells, Lysophosphatidic, Acid, Receptors, Tocris Bioscience
