Biological Activity
Histamine H1 receptor antagonist (Ki = 31.6 nM). Inhibits the release of histamine, prostaglandin D2 and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production.
Compound Libraries
Olopatadine hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 373.87 |
| Formula | C21H23NO3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 140462-76-6 |
| PubChem ID | 5282402 |
| InChI Key | HVRLZEKDTUEKQH-NOILCQHBSA-N |
| Smiles | O=C(CC(C=C3)=CC/1=C3OCC(C=CC=C2)=C2C1=CCCN(C)C)O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.39 | 100 | |
| water | 28.04 | 75 |
Preparing Stock Solutions
The following data is based on the product molecular weight 373.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.67 mL | 13.37 mL | 26.75 mL |
| 5 mM | 0.53 mL | 2.67 mL | 5.35 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.67 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Tamura et al (2007) Olopatidine ameliorates rat experimental cutaneous inflammation by improving skin barrier function. Pharmacology 81 118 PMID: 17962722
Sharif et al (1996) Characterization of the ocular antiallergic and antihistaminic effects of olopatidine (AL-4943A), a novel drug for treating ocular allergic diseases. J.Pharm.Exp.Ther. 278 1252 PMID:
Keywords: Olopatadine hydrochloride, supplier, histamine, H1, antagonists, antihistamines, mast, cell, stabilizers, ocular, antiallergic, Histamine, H1, Receptors, Histamine, H1, Receptors, Tocris Bioscience
