Biological Activity
Proapoptotic agent that induces abnormal nuclear aggregation of PKCι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo.
Technical Data
| M. Wt | 269.73 |
| Formula | C16H12ClNO |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 75629-57-1 |
| PubChem ID | 872445 |
| InChI Key | ZDRQMXCSSAPUMM-UHFFFAOYSA-N |
| Smiles | O=CC2=CN(CC3=CC=C(Cl)C=C3)C1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.97 | 100 | |
| ethanol | 6.74 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 269.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.71 mL | 18.54 mL | 37.07 mL |
| 5 mM | 0.74 mL | 3.71 mL | 7.41 mL |
| 10 mM | 0.37 mL | 1.85 mL | 3.71 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Guo et al (2009) Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). Mol.Cancer Ther. 8 441 PMID: 19208825
Guo et al (2007) Identification of a small molecule with synthetic lethality for k-Ras and protein kinase C iota. Cancer Res. 68 7403 PMID:
Keywords: Oncrasin 1, supplier, Induces, abnormal, nuclear, aggregation, PKCiota, proapoptotic, Protein, Kinases, C, Apoptosis, Inducers, Oncrasin1, Protein, Kinase, C, Apoptosis, Inducers, Protein, Kinase, C, Tocris Bioscience
