Biological Activity
Selective 5-HT3 receptor antagonist (Ki = 6.16 nM). Antiemetic; prevents emesis induced by cytotoxic drugs and radiation.
Technical Data
| M. Wt | 329.83 |
| Formula | C18H19N3O.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 99614-01-4 |
| PubChem ID | 68647 |
| InChI Key | MKBLHFILKIKSQM-UHFFFAOYSA-N |
| Smiles | CN1C3=C(C=CC=C3)C2=C1CCC(CN4C(C)=NC=C4)C2=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.98 | 100 | |
| ethanol | 8.25 | 25 | |
| water | 16.49 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 329.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.03 mL | 15.16 mL | 30.32 mL |
| 5 mM | 0.61 mL | 3.03 mL | 6.06 mL |
| 10 mM | 0.3 mL | 1.52 mL | 3.03 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.61 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Youssefyeh et al (1992) Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides. J.Med.Chem. 35 895 PMID: 1312602
Ye et al (2001) Ondansetron: a selective 5-HT3 receptor antagonist and its applications in CNS-related disorders. CNS Drug Rev. 7 199 PMID: 11474424
Ginawi et al (2005) Ondansetron, a selective antagonist, antagonizes methamphetamine-induced anorexia in mice. Pharmacol.Res. 51 255 PMID: 15661576
Keywords: Ondansetron hydrochloride, supplier, Selective, 5-HT3, antagonists, Serotonin, Receptors, GR38032, GR, 38032, 5-HT3, Receptors, 5-HT3, Receptors, Tocris Bioscience
