Biological Activity
Naturally occurring deoxybenzoin. TRPM3 channel blocker (IC50 = 300 nM). Inhibits pregnenolone sulfate-induced intracellular Ca2+ accumulation in HEKmTRPM3 cells and dorsal root ganglia (DRG) neurons in vitro.
Technical Data
| M. Wt | 258.27 |
| Formula | C15H14O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 487-49-0 |
| PubChem ID | 259632 |
| InChI Key | XHBZOAYMBBUURD-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(CC(C2=C(O)C=C(O)C=C2)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.83 | 100 | |
| ethanol | 25.83 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 258.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.87 mL | 19.36 mL | 38.72 mL |
| 5 mM | 0.77 mL | 3.87 mL | 7.74 mL |
| 10 mM | 0.39 mL | 1.94 mL | 3.87 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.77 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Straub et al (2012) Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. Br.J.Pharmacol. 168 1835 PMID: 23190005
Keywords: Ononetin, supplier, TRPM3, blockers, transient, receptor, potential, channels, TRPM, TRPM, Tocris Bioscience
