Biological Activity
Selective 5-HT2C receptor agonist (pEC50 values are 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2B respectively). Displays antiaversive effects in a rat model of panic-like anxiety.
Technical Data
| M. Wt | 302.12 |
| Formula | C10H11ClF3N3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 210821-63-9 |
| PubChem ID | 9796407 |
| InChI Key | FVDILXYXZAAJOS-UHFFFAOYSA-N |
| Smiles | ClC1=NC(N2CCNCC2)=CC=C1C(F)(F)F.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.21 | 100 | |
| water | 15.11 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 302.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.31 mL | 16.55 mL | 33.1 mL |
| 5 mM | 0.66 mL | 3.31 mL | 6.62 mL |
| 10 mM | 0.33 mL | 1.65 mL | 3.31 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
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References
References are publications that support the products' biological activity.
Jenck et al (1998) Antiaversive effects of 5-HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats. Eur.Neuropsychopharmacol. 8 161 PMID: 9716307
Porter et al (1999) Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br.J.Pharmacol. 128 13 PMID: 10498829
Halford et al (2005) Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr.Drug Targets 6 201 PMID: 15777190
Keywords: Org 12962 hydrochloride, supplier, 5-HT2C, agonist, Serotonin, Receptors, 5-HT2, Org12962, hydrochloride, 5-HT2C, Receptors, 5-HT2C, Receptors, Tocris Bioscience
