Tocris/Org 20599/2738/10/10 mg-免疫在线蚂蚁淘旗下平台

当前位置：首页 > 产品中心 > Signal_pathway > Tocris/Org 20599/2738/10/10 mg

商品详细Tocris/Org 20599/2738/10/10 mg

Tocris/Org 20599/2738/10/10 mg

商品编号： 2738/10

品牌： Tocris Bioscience

市场价： ¥3980.00

美元价： 2388.00

产地：美国(厂家直采)

公司：

产品分类：信号通路

公司分类： Signal_pathway

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

Description: Positive allosteric modulator and direct agonist of GABA_A receptors

Chemical Name: (2β,3α,5α)-21-Chloro-3-hydroxy-2-(4-morpholinyl)pregnan-20-one

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Positive allosteric modulator and at higher concentrations direct agonist of GABA_A receptors (EC₅₀ = 1.1 μM). Also displays positive modulation of glycine receptors (EC₅₀ = 22.9 μM). Anesthetic steroid; induces hypnosis and loss of righting reflexes in mice.

Technical Data

M. Wt	438.04
Formula	C₂₅H₄₀ClNO₃
Storage	Store at RT
CAS Number	156685-94-8
PubChem ID	9850026
InChI Key	NZFNABGZEQPYBX-PMBZPZLSSA-N
Smiles	O=[C@](CCl)[C@H]4CC[C@@]3([H])[C@]2([H])CC[C@@]1([H])C[C@H](O)[C@@H](N5CCOCC5)C[C@@](C)1[C@]([H])2CC[C@@]34C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	43.8	100
	DMSO	43.8	100

Preparing Stock Solutions

The following data is based on the product molecular weight 438.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.41 mL	22.83 mL
5 mM	0.46 mL	2.28 mL	4.57 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Hill-Venning et al (1996) The anaesthetic action and modulaton of GABA_A receptor activity by the novel water-soluble aminosteroid Org 20599. Neuropharmacology 35 1209 PMID: 9014136

Visser et al (2002) Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABA_A receptor in vivo. J.Pharmacol.Exp.Ther. 303 616 PMID: 12388643

Weir et al (2004) The interaction of anaesthetic steroids with recombinant glycine and GABA_A receptors. Br.J.Anaesth. 92 704 PMID: 15033889

Keywords: Org 20599, supplier, Positive, allosteric, modulators, direct, agonists, GABAA, receptors, Receptors, Org20599, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience

品牌介绍

Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。 Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。 Tocris Bioscience的主要产品包括： Small Molecules Peptides Aptamers Controlled Substances Compound Libraries DREADD Ligands Fluorescent Imaging Ligand Sets Optopharmacology Reagents Toxins 按照研究领域细分： Cancer Cardiovascular System Endocrinology Immunology Neuroscience Pain & Inflammation Respiratory System

公司介绍

品牌分类