Biological Activity
Peptide fragment containing amino acids 1-11 of Nociceptin (Cat. No. 0910). Potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM); displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Displays analgesic properties in CD-1 mice.
Technical Data
| M. Wt | 1098.2 |
| Formula | C49H75N15O14 |
| Sequence | FGGFTGARKSA |
| Storage | Store at -20°C |
| CAS Number | 178249-41-7 |
| PubChem ID | 10653748 |
| InChI Key | BBTOUBACUUPBRQ-KCKZSKPYSA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 2 mg/ml in 20% acetonitrile / water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1098.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.91 mL | 4.55 mL | 9.11 mL |
| 5 mM | 0.18 mL | 0.91 mL | 1.82 mL |
| 10 mM | 0.09 mL | 0.46 mL | 0.91 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.18 mL |
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References
References are publications that support the products' biological activity.
Rossi et al (1997) Pharmacological characterization of orphanin FQ/nociceptin and its fragments. J.Pharmacol.Exp.Ther. 282 858 PMID: 9262352
Rossi et al (1998) Orphanin FQ/nociceptin analgesia in the rat. Brain Res. 792 327 PMID: 9593974
Reinscheid et al (1996) Structure-activity relationship studies on the novel neuropeptide orphanin FQ. J.Biol.Chem. 271 14163 PMID: 8662940
Keywords: Orphanin FQ (1-11), supplier, Nociceptin, Receptors, agonists, NOP, ORL1, KOR-3, analgesic, opioid, Nociceptin, (1-11), NOP, Receptors, NOP, Receptors, Tocris Bioscience
