Biological Activity
Selective Na+, K+-ATPase inhibitor.
Technical Data
| M. Wt | 584.66 |
| Formula | C29H44O12 |
| Storage | Desiccate at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 630-60-4 |
| PubChem ID | 439501 |
| InChI Key | LPMXVESGRSUGHW-HBYQJFLCSA-N |
| Smiles | O[C@@]12[C@@]3([H])[C@]([C@]([C@H](O)C[C@@H](O[C@@H]6O[C@@H](C)[C@H](O)[C@@H](O)[C@H]6O)C4)(CO)[C@]4(O)CC3)([H])[C@H](O)C[C@@](C)1[C@@H]([C@@](CO5)=CC5=O)CC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.47 | 100 | |
| ethanol | 50 | ||
| water | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 584.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.71 mL | 8.55 mL | 17.1 mL |
| 5 mM | 0.34 mL | 1.71 mL | 3.42 mL |
| 10 mM | 0.17 mL | 0.86 mL | 1.71 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Croyle et al (1997) Extensive random mutagenesis analysis of the Na/K+ ATPase alpha subunit identifies known and previously unidentified amino acid residues that alter ouabain sensitivity-implications for ouabain binding. Eur.J.Biochem. 248 488 PMID: 9346307
Hosoi et al (1997) Isoform-specific up-regulation by ouabain of Na+, K+-ATPase in cultured rat astrocytes. J.Neurochem. 69 2189 PMID: 9349566
Marjorie et al (1997) Ouabain improves cardiac function in vivo in rats with heart failure after chronic but not acute treatment. Naunyn Schmiedebergs Arch.Pharmacol. 356 203 PMID: 9272726
Merck Index 12 7031 PMID:
Keywords: Ouabain, supplier, Na+K+-ATPases, inhibitors, inhibits, Ion, Pumps, Transporters, Na+/K+, ATPase, Na+/K+, ATPase, Tocris Bioscience
