Biological Activity
Muscarinic receptor agonist. Also directly potentiates NMDA-mediated ion currents.
Technical Data
| M. Wt | 322.19 |
| Formula | C11H19IN2O |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 3854-04-4 |
| PubChem ID | 3027782 |
| InChI Key | VVLMSCJCXMBGDI-UHFFFAOYSA-M |
| Smiles | O=C1N(CC#CC[N+](C)(C)C)CCC1.[I-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 32.22 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 322.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.1 mL | 15.52 mL | 31.04 mL |
| 5 mM | 0.62 mL | 3.1 mL | 6.21 mL |
| 10 mM | 0.31 mL | 1.55 mL | 3.1 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Birdsall et al (1978) The binding of agonists to brain muscarinic receptors. Mol.Pharmacol. 14 723 PMID: 714021
Kukkonen et al (1996) Functional properties of muscarinic receptor subtypes Hm1, Hm3 and Hm5 expressed in Sf9 cells using the baculovirus expression system. J.Pharmacol.Exp.Ther. 279 593 PMID: 8930161
Zwart et al (2017) Oxotremorine-M potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms. Biochem.Biophys.Res.Commun. PMID: 29127015
Keywords: Oxotremorine M, supplier, Muscarinic, agonists, Receptors, Acetylcholine, ACh, OxotremorineM, NMDA, potentiator, potentiates, Non-selective, Muscarinics, NMDA, Receptors, Non-selective, Muscarinics, Tocris Bioscience
