BiologicalActivity
Resorcycliclactoneoffungaloriginthatactsasapotentandselectivetransforminggrowthfactor-β-activatedkinase1(TAK1)mitogen-activatedproteinkinasekinasekinase(MAPKKK)inhibitor(IC50=8nM).Displays>33-foldand>62-foldselectivityoverMEKK1andMEKK4respectively.InhibitsIL-1-inducedactivationofNF-κB(IC50=83nM)andJNK/p38.Inhibitsproductionofinflammatorymediators,andsensitizescellstoTRAIL-andTNF-α-inducedapoptosisinvitro.
TechnicalData
| M.Wt | 362.37 |
| Formula | C19H22O7 |
| Storage | Desiccateat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 253863-19-3 |
| PubChemID | 9799061 |
| InChIKey | NEQZWEXWOFPKOT-ULSULSEOSA-N |
| Smiles | O=C/2[C@@H](O)[C@@H](O)C/C=C/C1=CC(OC)=CC(O)=C1C(O[C@@H](C)CC=C2)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.06 | 25 | |
| ethanol | 3.62 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight362.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.76mL | 13.8mL | 27.6mL |
| 5mM | 0.55mL | 2.76mL | 5.52mL |
| 10mM | 0.28mL | 1.38mL | 2.76mL |
| 50mM | 0.06mL | 0.28mL | 0.55mL |
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