Biological Activity
Protein disulfide isomerase (PDI) inhibitor (IC50 = 1.7 μM). Inhibits proliferation of numerous cancer cell lines. Cell permeable.
Technical Data
| M. Wt | 583.7 |
| Formula | C30H37N3O7S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1461648-55-4 |
| PubChem ID | 91826082 |
| InChI Key | RNMDSOKRNOMQFX-UIOOFZCWSA-N |
| Smiles | O=[C@@](NCCCC#C)[C@@H](NC([C@@H](NC(OC(C)(C)C)=O)CC2=CC=CC=C2)=O)CC1=CC=C(OS(C=C)(=O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.37 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 583.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.71 mL | 8.57 mL | 17.13 mL |
| 5 mM | 0.34 mL | 1.71 mL | 3.43 mL |
| 10 mM | 0.17 mL | 0.86 mL | 1.71 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Ge et al (2013) Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase ACS Chem.Biol. 8 2577 PMID: 24070012
Xu et al (2013) Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization. PLoS One 8 e76657 PMID: 24098548
Keywords: P1, supplier, Protein, disulfide, Isomerase, PDI, inhibitors, inhibits, Protein, Disulfide, Isomerase, Protein, Disulfide, Isomerase, Tocris Bioscience
