Biological Activity
Selective antagonist of neurosteroid potentiation and direct gating of GABAA receptors. Selectively reduces the effects of 5α-reduced steroids compared to 5β-reduced steroids and displays no effect on potentiation evoked by barbiturates and benzodiazepines. Attenuates 3α,5α-THP-induced loss of righting reflex and total sleep time following i.c.v administration in rats.
Technical Data
| M. Wt | 350.54 |
| Formula | C25H34O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 694438-95-4 |
| PubChem ID | 5281004 |
| InChI Key | VOVIALXJUBGFJZ-KWVAZRHASA-N |
| Smiles | O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3C[C@@H]5[C@](C(CO)=O)4OC(CCC)O5)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.76 | 25 | |
| ethanol | 17.53 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 350.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.26 mL | 28.53 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.71 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
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References
References are publications that support the products' biological activity.
Mennerick et al (2004) Selective antagonism of 5α-reduced neurosteroid effects at GABAA receptors. Mol.Pharmacol. 65 1191 PMID: 15102947
Akk et al (2007) Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the α1β2γ2L GABAA receptor. Mol.Pharmacol. 71 461 PMID: 17105870
Kelley et al (2007) Antagonism of neurosteroid modulaton of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol. Eur.J.Pharmacol. 572 94 PMID: 17658511
Keywords: 17-PA, supplier, antagonists, neurosteroid, potentiation, direct, gating, GABAA, Receptors, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
