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Tocris/PCNA I1/5419/50/50毫克

商品编号： 5419/50

品牌： Tocris Bioscience

市场价： ¥11700.00

美元价： 7020.00

产地：美国(厂家直采)

公司：

产品分类：合成

公司分类： Synthesis

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PCNAinhibitor

ChemicalName:N-(3-Methylthiophene-2-carboxylicacid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Proliferatingcellnuclearantigen(PCNA)inhibitor.DirectlybindsPCNAtrimers(K_d=0.41μM),reduceschromatin-associatedPCNAincells,inhibitscellgrowththroughinductionofSandG₂Marrest,andattenuatesDNAreplicationincells.InhibitsgrowthofarangeoftumorcelllinesinvitrowithIC₅₀valuesinthenanomolartolowmicromolarrange.Inhibitsgrowthofprostatetumorxenograftsinmice.

TechnicalData

M.Wt	310.37
Formula	C₁₇H₁₄N₂O₂S
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	444930-42-1
PubChemID	5410824
InChIKey	WNYIQPCMVYAJLQ-JLHYYAGUSA-N
Smiles	O=C(C1=C(C)C=CS1)N/N=C/C2=C(O)C3=CC=CC=C3C=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	31.04	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight310.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.22mL	16.11mL	32.22mL
5mM	0.64mL	3.22mL	6.44mL
10mM	0.32mL	1.61mL	3.22mL
50mM	0.06mL	0.32mL	0.64mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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