Biological Activity
Human ether-a-go-go (hERG) KV11.1 potassium channel activator. Displays no major effect on INa, ICa/L, IK1 and IKs currents. Causes resting membrane hyperpolarization and decreases action potential duration in rat myocytes in vitro.
Technical Data
| M. Wt | 386.27 |
| Formula | C21H17Cl2NO2 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 313674-97-4 |
| PubChem ID | 9864959 |
| InChI Key | ZCQOSCDABPVAFB-UHFFFAOYSA-N |
| Smiles | ClC(C(Cl)=C3)=CC=C3CCC(C=C2)=CC=C2NC1=C(C(O)=O)C=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.63 | 100 | |
| ethanol | 7.73 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 386.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.59 mL | 12.94 mL | 25.89 mL |
| 5 mM | 0.52 mL | 2.59 mL | 5.18 mL |
| 10 mM | 0.26 mL | 1.29 mL | 2.59 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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References
References are publications that support the products' biological activity.
Zhou et al (2005) Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity. Mol.Pharmacol. 68 876 PMID: 15976038
Yeung and Greenwood (2007) Pharmacological and biophysical isolation of K+ currents encoded by ether-a-go-go-related genes in murine hepatic portal vein smooth muscle cells. Am.J.Physiol.Cell.Physiol. 292 C468 PMID: 16870833
Duff (2008) hERG: The long and short of it. Heart Rhythm 5 591 PMID: 18362028
Keywords: PD 118057, supplier, Human, ether-a-go-go, hERG, K+, potassium, KV, channels, activators, voltage-gated, voltage-dependent, PD118057, KV11.1, Voltage-Gated, Potassium, Channels, Voltage-Gated, Potassium, Channels, Tocris Bioscience
