Biological Activity
Potent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.
Technical Data
| M. Wt | 736.67 |
| Formula | C31H32N4O3.2CF3CO2H |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 130663-39-7 |
| PubChem ID | 6604951 |
| InChI Key | GPKQIEZLHVGJQH-ZXVJYWQYSA-N |
| Smiles | O=C(C(C5=CC=CC=C5)C4=CC=CC=C4)N1[C@H]([C@](O)=O)CC(N(CC3=CC(C)=C(N(C)C)C=C3)C=N2)=C2C1.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 51.06 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 736.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.36 mL | 6.79 mL | 13.57 mL |
| 5 mM | 0.27 mL | 1.36 mL | 2.71 mL |
| 10 mM | 0.14 mL | 0.68 mL | 1.36 mL |
| 50 mM | 0.03 mL | 0.14 mL | 0.27 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Blankley et al (1991) Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. J.Med.Chem. 34 3248 PMID: 1956044
Boulay et al (1992) Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP-753-sensitive angiotensin II receptor of bovine adrenal glomerulosa. Mol.Pharmacol. 41 809 PMID: 1569928
Tamura et al (2000) Induction of angiotensin II subtype 2 receptor-mediated blood pressure regulation in synthetic diet-fed rats. J.Hypertens. 18 1239 PMID: 10994755
Keywords: PD 123319 ditrifluoroacetate, supplier, Potent, selective, non-peptide, AT2, antagonists, Receptors, Angiotensin, PD123319, ditrifluoroacetate, Angiotensin, AT2, Receptors, Angiotensin, AT2, Receptors, Tocris Bioscience
