Biological Activity
Potent D3 dopamine receptor agonist (Ki = 2.3 nM). Displays 18 - 200-fold selectivity over other dopamine receptor subtypes.
Technical Data
| M. Wt | 285.77 |
| Formula | C14H19NO3.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 300576-59-4 |
| PubChem ID | 11957668 |
| InChI Key | DCFXOTRONMKUJB-QMDUSEKHSA-N |
| Smiles | CCCN3[C@@H]2COC1=CC=C(O)C=C1[C@H]2OCC3.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 10 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 285.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.5 mL | 17.5 mL | 34.99 mL |
| 5 mM | 0.7 mL | 3.5 mL | 7 mL |
| 10 mM | 0.35 mL | 1.75 mL | 3.5 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
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References
References are publications that support the products' biological activity.
Bristow et al (1996) The behavioural and neurochemical profile of the putative dopamine D3 receptor agonist, (+)-PD 128907, in the rat. Neuropharmacology 35 285 PMID: 8783203
Pugsley et al (1995) Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907. J.Pharmacol.Exp.Ther. 275 1355 PMID: 8531103
Witkin et al (1998) Atypical antipsychotic-like effects of the dopamine D3 receptor agonist (+)-PD 128907. Eur.J.Pharmacol. 347 R1 PMID: 9741997
Keywords: (+)-PD 128907 hydrochloride, supplier, D3, agonists, D2, D4, Dopamine, Receptors, dopaminergic, (+)-PD128907, hydrochloride, PD128907, D3, Receptors, D3, Receptors, Tocris Bioscience
