Biological Activity
Selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). Targets the calcium binding sites of calpain. Demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate.
Technical Data
M. Wt | 306.12 |
Formula | C9H7IO2S |
Storage | Store at -20°C |
Purity | ≥95% (HPLC) |
CAS Number | 179528-45-1 |
PubChem ID | 9839500 |
InChI Key | DJCVSFWGKYHMKH-YVMONPNESA-N |
Smiles | IC1=CC=C(/C=C(C(O)=O)S)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 30.61 | 100 | |
ethanol | 15.31 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 306.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.27 mL | 16.33 mL | 32.67 mL |
5 mM | 0.65 mL | 3.27 mL | 6.53 mL |
10 mM | 0.33 mL | 1.63 mL | 3.27 mL |
50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
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References
References are publications that support the products' biological activity.
Squier et al (1999) Calpain and calpastatin regulate neutrophil apoptosis. J.Cell Physiol. 178 311 PMID: 9989777
Wang et al (1996) An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc.Natl.Acad.Sci.U.S.A. 93 6687 PMID: 8692879
Waters et al (1997) Calpains mediate calcium chloride influx during the late phase of cell injury. J.Pharmacol.Exp.Ther. 283 1177 PMID: 9399991
Keywords: PD 150606, supplier, PD150606, calpain, inhibitors, inhibits, selective, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, Proteinases, Proteases, Calcium-Sensitive, Proteases, Calpains, Calpains, Tocris Bioscience