BiologicalActivity
Potentinhibitorofthetyrosinekinasesc-Src,fibroblastgrowthfactorreceptor1(FGFR1),andplatelet-derivedgrowthfactorreceptorβ(PDGFRβ)(IC50valuesare8.4,39.3and98.3nMrespectively).AlsoinhibitsthecheckpointkinasesWee1andMyt1;abolishesCdc2phosphorylationinnumeroustumorcelllinesandabrogatestheG2checkpoint.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
CompoundLibraries
PD166285dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 585.35 |
| Formula | C26H27Cl2N5O2.2HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 212391-63-4 |
| PubChemID | 9916391 |
| InChIKey | NADLBPWBFGTESN-UHFFFAOYSA-N |
| Smiles | CN(C1=NC(NC4=CC=C(OCCN(CC)CC)C=C4)=NC=C1C=C2C3=C(Cl)C=CC=C3Cl)C2=O.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.53 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight585.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.71mL | 8.54mL | 17.08mL |
| 5mM | 0.34mL | 1.71mL | 3.42mL |
| 10mM | 0.17mL | 0.85mL | 1.71mL |
| 50mM | 0.03mL | 0.17mL | 0.34mL |
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ProductDatasheets
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