Biological Activity
Potent and selective dopamine D4 receptor antagonist (Ki values are 8.8 and 1842 nM at D4 and D2 receptors respectively). Reverses amphetamine-stimulated locomotion in vivo and is orally active.
Compound Libraries
PD 168568 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 422.39 |
| Formula | C22H27N3O.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 210688-56-5 |
| PubChem ID | 56972231 |
| InChI Key | RMNWLEGGYCVHFD-UHFFFAOYSA-N |
| Smiles | CC1=C(C)C=CC(N2CCN(CCC(N4)C3=CC=CC=C3C4=O)CC2)=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.24 | 100 | |
| water | 21.12 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 422.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.37 mL | 11.84 mL | 23.67 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.73 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.37 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Belliotti et al (1998) Isoindolinone enantiomers having affinity for the dopamine D4 receptor. Bioorg.Med.Chem.Lett. 8 1499 PMID: 9873377
Keywords: PD 168568 dihydrochloride, supplier, Potent, selective, D4, antagonists, Dopamine, Receptors, dopaminergic, PD168568, dihydrochloride, D4, Receptors, D4, Receptors, Tocris Bioscience
