BiologicalActivity
SelectiveFGFR1andFGFR3inhibitor(IC50valuesare5,21.5,~100,17600and19800nMforFGFR3,FGFR1,VEGFR2,PDGFRandc-Srcrespectively,and>50000nMforEGFR,InsR,MEKandPKC).InhibitsVEGF-andFGF-inducedangiogenesisinthemousecorneamodelofangiogenesis.InhibitsproliferationanddifferentiationofoligodendrocyteProgenitors.SuppressescellproliferationincelllinesexpressingmutatedFGFR3protein.BlockstumorgrowthinH510andH69SCLCxenograftmodels.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
CompoundLibraries
PD173074isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 523.67 |
| Formula | C28H41N7O3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 219580-11-7 |
| PubChemID | 1401 |
| InChIKey | DXCUKNQANPLTEJ-UHFFFAOYSA-N |
| Smiles | O=C(NC(C)(C)C)NC2=NC1=NC(NCCCCN(CC)CC)=NC=C1C=C2C3=CC(OC)=CC(OC)=C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.37 | 100 | |
| ethanol | 52.37 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight523.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.91mL | 9.55mL | 19.1mL |
| 5mM | 0.38mL | 1.91mL | 3.82mL |
| 10mM | 0.19mL | 0.95mL | 1.91mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |
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ProductDatasheets
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