Biological Activity
Inhibitor of MEK1. Analog of PD 184352 (Cat. No. 4237).
Technical Data
| M. Wt | 545.3 |
| Formula | C20H19F3IN5O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 548756-68-9 |
| PubChem ID | 5287529 |
| InChI Key | LZZYEMSEMRUPIM-UHFFFAOYSA-N |
| Smiles | FC1=CC(I)=CC=C1NC2=C(F)C(F)=CC=C2C3=NN=C(NCCN4CCOCC4)O3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 54.53 | 100 | |
| ethanol | 5.45 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 545.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.83 mL | 9.17 mL | 18.34 mL |
| 5 mM | 0.37 mL | 1.83 mL | 3.67 mL |
| 10 mM | 0.18 mL | 0.92 mL | 1.83 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.37 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Zhang et al (2009) Targeting cancer with small molecule kinase inhibitors. Nat.Rev.Cancer 9 28 PMID: 19104514
Ohren et al (2004) Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel competitive kinase inhibition. Nat.Struct.Mol.Biol. 11 1192 PMID: 15543157
Keywords: PD 334581, supplier, PD334581, MEK1, kinase, inhibitors, inhibits, mitogen, activated, protein, kinase, 1, MEK, MEK, Tocris Bioscience
