Biological Activity
High affinity inhibitor of KDO 8-P synthase (Ki = 26 nM). Also inhibits dimethylarginine dimethylaminohydrolase 1 (DDAH1). Exhibits antiangiogenic and antiviral activity in vitro. Putative antibiotic against gram-negative bacteria.
Technical Data
| M. Wt | 217.29 |
| Formula | C11H11N3S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 72596-74-8 |
| PubChem ID | 6603967 |
| InChI Key | JNENSSREQFBZGT-UHFFFAOYSA-N |
| Smiles | N=C2SC1=CC=CC=C1C3=NCCCN23 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 21.73 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 217.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.6 mL | 23.01 mL | 46.02 mL |
| 5 mM | 0.92 mL | 4.6 mL | 9.2 mL |
| 10 mM | 0.46 mL | 2.3 mL | 4.6 mL |
| 50 mM | 0.09 mL | 0.46 mL | 0.92 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Birck et al (2000) Identification of a slow tight-binding inhibitor of 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase. J.Am.Chem.Soc. 122 9334 PMID:
Ghebremariam et al (2013) A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. J.Pharmacol.Exp.Ther. 348 69 PMID: 24135074
Chamoun-Emanuelli et al (2014) Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide. Antimicrob.Agents Chemother. 58 687 PMID: 24217696
Keywords: PD 404182, supplier, PD404182, antibiotics, KDO8-P, antivirals, antiangiogenics, angiogenesis, gram, negative, DDAH1, 3-deoxy-D-manno-octulosonic, acid, 8-phosphate, synthase, dimethylarginine, dimethylaminohydrolase, 1, inhibits, inhibitors, Other, Synthases/Synthetases, Other, Hydrolases, Other, Synthases/Synthetases, Tocris Bioscience
