BiologicalActivity
SelectiveinhibitorofcheckpointkinasesChk1andWee1(IC50valuesare47and97nMrespectively).Displaysselectivityoverarangeofotherproteinkinases;IC50valuesare3.4,3.75,>5,>50,>50and>50μMforPKC,CDK4,otherCDKs,c-Src,PDGFRandFGFRrespectively.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
CompoundLibraries
PD407824isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 328.32 |
| Formula | C20H12N2O3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 622864-54-4 |
| PubChemID | 4369491 |
| InChIKey | IAUZTOZLTFSMIE-UHFFFAOYSA-N |
| Smiles | OC1=CC2=C(NC3=C2C2=C(C(=O)NC2=O)C(=C3)C2=CC=CC=C2)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.83 | 100 | |
| ethanol | 8.2 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight328.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.05mL | 15.23mL | 30.46mL |
| 5mM | 0.61mL | 3.05mL | 6.09mL |
| 10mM | 0.3mL | 1.52mL | 3.05mL |
| 50mM | 0.06mL | 0.3mL | 0.61mL |
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