BiologicalActivity
Inhibitorofmitogen-activatedproteinkinasekinase(MKK/MEK).ActsbybindingtotheinactivatedformofMEK,therebypreventingitsphosphorylationbycRAForMEKkinase(IC50=2-7μM).Inhibitscellgrowthandproliferationinacutemyelogenousleukemia(AML)celllines;causesG1arrestbyblockingp53-dependentp21induction.Enhancesembryonicstemcellself-renewal.AlsoavailableaspartoftheMAPKCascadeInhibitorTocriset™andMAPKInhibitorTocriset™.
CompoundLibraries
PD98059isalsoofferedaspartoftheTocriscreenPlus,TocriscreenKinaseInhibitorToolboxIandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 267.28 |
| Formula | C16H13NO3 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 167869-21-8 |
| PubChemID | 9794588 |
| InChIKey | PKDHDJBNEKXCBI-UHFFFAOYSA-N |
| Smiles | COC1=C(N)C(=CC=C1)C1=CC(=O)C2=CC=CC=C2O1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.68 | 25 | |
| ethanol | 1.34 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight267.28.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.74mL | 18.71mL | 37.41mL |
| 5mM | 0.75mL | 3.74mL | 7.48mL |
| 10mM | 0.37mL | 1.87mL | 3.74mL |
| 50mM | 0.07mL | 0.37mL | 0.75mL |
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ProductDatasheets
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