Biological Activity
Potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™.
Technical Data
| M. Wt | 159.14 |
| Formula | C6H9NO4 |
| Storage | Store at RT |
| Purity | ≥97% (HPLC) |
| CAS Number | 64769-66-0 |
| PubChem ID | 1515192 |
| InChI Key | NRSBQSJHFYZIPH-DMTCNVIQSA-N |
| Smiles | O=[C@]([C@H]1NC[C@H]([C@@](O)=O)C1)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 15.91 | 100 | |
| 1eq. NaOH | 15.91 | 100 | |
| water | 15.91 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 159.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.28 mL | 31.42 mL | 62.84 mL |
| 5 mM | 1.26 mL | 6.28 mL | 12.57 mL |
| 10 mM | 0.63 mL | 3.14 mL | 6.28 mL |
| 50 mM | 0.13 mL | 0.63 mL | 1.26 mL |
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Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Bridges et al (1991) Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer. J.Med.Chem. 34 717 PMID: 1671706
Mitrovic and Johnston (1994) Regional differences in the inhibition of L-glutamate amd L-aspartate sodium-dependent high affinity uptake systems in rat CNS synaptosomes by L-trans-pyrrolidine-2,4-dicarboxylic threo-3-hydroxy-D-aspartate and D-aspartate. Neurochem.Int. 24 583 PMID: 7981641
Zuiderwijk et al (1996) Effects of uptake carrier blockers SK & F 89976-A and L-trans-PDC on in vivo release of amino acids in rat hippocampus. Eur.J.Pharmacol. 307 275 PMID: 8836615
Keywords: L-trans-2,4-PDC, supplier, potent, competitive, Transportable, EAAT1-4, EAAT2, EAAT3, EAAT4, inhibitors, inhibits, non-transportable, EAAT5, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, reuptake, trans-4-Carboxy-L-proline, Glutamate, Transporters, Glutamate, Transporters, Tocris Bioscience
