BiologicalActivity
Potentandselectivepoly(ADPribose)glycohydrolase(PARG)inhibitor(IC50=26nM).Exhibits>350-foldselectivityforPARGoverapanelofionchannels,enzymesandreceptors,includingPARP1andARH3.MaintainsPARchainsandinducesDNAdouble-strandedbreaksincellsfollowingDNAdamage.DecreasescolonyformationofZR-75-1BRCA1WTcells.Cellpermeable.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofPDD00017273isreviewedonthechemicalprobeswebsite.
TechnicalData
| M.Wt | 514.62 |
| Formula | C23H26N6O4S2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1945950-21-9 |
| PubChemID | 121398766 |
| InChIKey | IFWUBRBMMNTBRZ-UHFFFAOYSA-N |
| Smiles | O=C(C1=CC(S(NC2(CC2)C)(=O)=O)=CC=C1N3CC4=CC(C)=NN4C)N(CC5=CN=C(C)S5)C3=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.46 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight514.62.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.94mL | 9.72mL | 19.43mL |
| 5mM | 0.39mL | 1.94mL | 3.89mL |
| 10mM | 0.19mL | 0.97mL | 1.94mL |
| 50mM | 0.04mL | 0.19mL | 0.39mL |
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