BiologicalActivity
ATP-competitiveinhibitorofAurorakinasesAandB(IC50valuesare0.8and5nMforrecombinantAuroraBandAuroraA,respectively).InhibitsphosphorylationofAuroraB,histoneH3andAuroraAinculturedMDA-MB-231cells(IC50valuesareapproximately20,50and150nMrespectively).Showntoblockcytokinesis;inhibitscellularproliferationinseveralhumantumorcelllines,includingHCT-116,HL-60,A549andH125,andinhumanxenograftmousemodels.Orallyavailable.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
CompoundLibraries
PF03814735isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 474.48 |
| Formula | C23H25F3N6O2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 942487-16-3 |
| PubChemID | 51346455 |
| InChIKey | RYYNGWLOYLRZLK-RBUKOAKNSA-N |
| Smiles | [H][C@@]3(N5C(CNC(C)=O)=O)CC[C@@]5([H])C(C3=C4)=CC=C4NC1=NC(NC2CCC2)=C(C(F)(F)F)C=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.45 | 100 | |
| ethanol | 9.49 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight474.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.11mL | 10.54mL | 21.08mL |
| 5mM | 0.42mL | 2.11mL | 4.22mL |
| 10mM | 0.21mL | 1.05mL | 2.11mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |
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