BiologicalActivity
PotentEP2receptorantagonist(IC50=16nMforhumanEP2receptors).Displaysover2000-foldselectivityforEP2receptorsoverEP1,EP3,EP4,DP1amdCRTH2receptors;exhibits<30%bindingatadiversepanelofGPCRsandionchannelsataconcentrationof10μM.InhibitsPGE2-inducedincreasesinintracellularcAMP;reversesPGE2-invokedrelaxationofmousetrachea(IC50=2.7nM).
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
CompoundLibraries
PF04418948isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 409.41 |
| Formula | C23H20FNO5 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1078166-57-0 |
| PubChemID | 25114442 |
| InChIKey | LWJGMYMNSNVCEM-UHFFFAOYSA-N |
| Smiles | FC(C=C4)=CC=C4C(N(C3)CC3(C(O)=O)COC2=CC1=CC=C(OC)C=C1C=C2)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.94 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight409.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.44mL | 12.21mL | 24.43mL |
| 5mM | 0.49mL | 2.44mL | 4.89mL |
| 10mM | 0.24mL | 1.22mL | 2.44mL |
| 50mM | 0.05mL | 0.24mL | 0.49mL |
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ProductDatasheets
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