Tocris/PF 04671536 hydrochloride/6024/25/25 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/PF 04671536 hydrochloride/6024/25/25 mg

Tocris/PF 04671536 hydrochloride/6024/25/25 mg

商品编号： 6024/25

品牌： Tocris Bioscience

市场价： ¥6180.00

美元价： 3708.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentandselectivePDE8B/8Ainhibitor

ChemicalName:5-Methyl-3-[[(2R)-4-(2-thiazolylmethyl)-2-morpholinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-aminehydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectivePDE8B/8Ainhibitor(IC₅₀valuesare1.3and1.9nM,respectively).ExhibitsselectivityforPDE8A/BoverotherPDEs(IC₅₀valuesare>10μM)andarangeofothertargets.Increasesglucose-dependentinsulinsecretionfromhumanpacreaticisletcells.Orallybioavailable.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc

TechnicalData

M.Wt	382.87
Formula	C₁₄H₁₈N₈OS.HCl
Storage	DesiccateatRT
Purity	≥98%(HPLC)
CASNumber	1305116-67-9
InChIKey	KNBIGIZPAKPDTF-HNCPQSOCSA-N
Smiles	CC1=NC(N)=C2N=NN(C2=N1)C[C@H]3CN(CCO3)CC4=NC=CS4.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	water	7.66	20mMwithgentlewarming
	DMSO	38.29	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight382.87.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.61mL	13.06mL	26.12mL
5mM	0.52mL	2.61mL	5.22mL
10mM	0.26mL	1.31mL	2.61mL
50mM	0.05mL	0.26mL	0.52mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

LicensingInformation

TechnicalData

SolubilityData

PreparingStockSolutions

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