Tocris/PF 06273340/6115/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/PF 06273340/6115/10/10 mg

Tocris/PF 06273340/6115/10/10 mg

商品编号： 6115/10

品牌： Tocris Bioscience

市场价： ¥3380.00

美元价： 2028.00

产地：美国(厂家直采)

公司：

产品分类：激酶

公司分类： kinase

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:Potentandselectivepan-Trkinhibitor;peripherallyrestricted

ChemicalName:N-[5-[[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-2-pyridineacetamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectivepan-Trkinhibitor(IC₅₀valuesare1,2and6nMforTrkC,BandA,respectively).SelectiveforTrkoverapanelofionchannels,receptorsandotherenzymes.Peripherallyrestricted.Exhibitsefficacyinarodentmodelofinflammatorypain.Orallybioavailable.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

TechnicalData

M.Wt	479.93
Formula	C₂₃H₂₂ClN₇O₃
Storage	StoreatRT
Purity	≥98%(HPLC)
CASNumber	1402438-74-7
PubChemID	66571548
InChIKey	BPIWZDNVMQQBQX-UHFFFAOYSA-N
Smiles	NC1=NC=C2C(N(C(C)(C)CO)C=C2C(C3=CN=CC(NC(CC4=CC=C(Cl)C=N4)=O)=C3)=O)=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	47.99	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight479.93.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.08mL	10.42mL	20.84mL
5mM	0.42mL	2.08mL	4.17mL
10mM	0.21mL	1.04mL	2.08mL
50mM	0.04mL	0.21mL	0.42mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

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SolubilityData

PreparingStockSolutions

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