Tocris/PF 06409577/6114/50/50 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/PF 06409577/6114/50/50 mg

Tocris/PF 06409577/6114/50/50 mg

商品编号： 6114/50

品牌： Tocris Bioscience

市场价： ¥13380.00

美元价： 8028.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentandselectiveallostericactivatorofAMPK

ChemicalName:6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylicacid

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveallostericactivatorofAMPK(EC₅₀valuesare7and>40000nMforAMPKα1β1γ1andAMPKα1β2γ1,respectively).Exhibitsminimaloff-targeteffectsonapanelofreceptors,ionchannels,PDEsandkinases.Improveskidneyfunctionandreducesproteinuriainapreclinicalmodelofdiabeticnephropathy.Orallybioavailable.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

TechnicalData

M.Wt	341.79
Formula	C₁₉H₁₆ClNO₃
Storage	StoreatRT
Purity	≥98%(HPLC)
CASNumber	1467057-23-3
PubChemID	71748255
InChIKey	FHQXLWCFSUSXBF-UHFFFAOYSA-N
Smiles	O=C(O)C1=CNC2=CC(Cl)=C(C3=CC=C(C4(CCC4)O)C=C3)C=C21

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	34.18	100
	ethanol	6.84	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight341.79.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.93mL	14.63mL	29.26mL
5mM	0.59mL	2.93mL	5.85mL
10mM	0.29mL	1.46mL	2.93mL
50mM	0.06mL	0.29mL	0.59mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

LicensingInformation

TechnicalData

SolubilityData

PreparingStockSolutions

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