Tocris/PF 06424439/6348/5/5 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/PF 06424439/6348/5/5 mg

Tocris/PF 06424439/6348/5/5 mg

商品编号： 6348/5

品牌： Tocris Bioscience

市场价： ¥1380.00

美元价： 828.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentandselectiveDGAT2inhibitor

ChemicalName:[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinylmethanonemethanesulfonate

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveDGAT2inhibitor(IC₅₀=14nM).ExhibitsnosignificantactivityatMGAT1-3orDGAT1.Reducestriglyderidesynthesisinhumanhepatocytesinvitro.Reducesplasmatriglycerideandcholesterollevelsinaratdyslipidemiamodel.Orallybioavailable.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

TechnicalData

M.Wt	536.05
Formula	C₂₂H₂₆ClN₇O.CH₄O₃S
Storage	DesiccateatRT
Purity	≥98%(HPLC)
CASNumber	1469284-79-4
PubChemID	89854212
InChIKey	ZSTFDNQQOJUJFL-XFULWGLBSA-N
Smiles	ClC(C=N1)=CN1C2(CC2)C3=NC4=CC=C(N5C[C@H](C(N6CCCC6)=O)CCC5)N=C4N3.O=S(C)(O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	water	53.6	100
	DMSO	53.6	100
	ethanol	53.6	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight536.05.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.87mL	9.33mL	18.65mL
5mM	0.37mL	1.87mL	3.73mL
10mM	0.19mL	0.93mL	1.87mL
50mM	0.04mL	0.19mL	0.37mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

LicensingInformation

TechnicalData

SolubilityData

PreparingStockSolutions

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